Current Funding

National Institutes of Health (NIGMS)
R15 Academic Research Enhancement Award (AREA) for Undergraduate Institutions
“Function and dynamics of rotor-stator interactions in the proton-translocating Fo motor of ATP synthase”

National Institutes of Health (NIAID)
R15 Academic Research Enhancement Award (AREA) for Undergraduate Institutions
“Targeted development and selective delivery of small molecule antibiotics for the treatment of multidrug resistant Pseudomonas aeruginosa infections”

Relevant Publications

  • Shrestha, R.K., Founds, M.W., Rothrock, M.M., Shepard, S.J., Defnet, A.E., and Steed, P.R. (2023) “Mutational analysis of a conserved positive charge in the c-ring of E. coli ATP synthase.” BBA-Bioenergetics. 1864, 148962
  • Ciprich, J., Buckhalt, A.J.E., Carroll, L.L., Chen, D., Defiglia, S.A., McConnell, R.S., Parmar, D.J., Pistor, O.L., Rao, A.B., Rubin, M.L., Volk, G.E., Steed, P.R., and Wolfe, A.L. (2022) “Synthesis and evaluation of Pseudomonas aeruginosa ATP synthase inhibitors.” ACS Omega. 7, 28434-28444.
  • Steed, P.R., Kraft, K., and Fillingame, R.H. (2014) “Interacting Cytoplasmic Loops of Subunits a and c of Escherichia coli F1F0 ATP Synthase Gate H+ Transport to the Cytoplasm.” Proc. Natl. Acad. Sci. USA. 111, 16730.
  • Fillingame, R.H. and Steed, P.R. (2014) “Half channels mediating H+ transport and the mechanism of gating in the Fo sector of Escherichia coli F1Fo ATP synthase.” Biochim. Biophys. Acta. 1837,1063. (Review)
  • Steed, P.R. and Fillingame, R.H. (2014) “Residues in the Subunit c Loopof Escherichia coli ATP Synthase Function in Gating H+ Transport to the Cytoplasm.” J. Biol. Chem. 289, 2127.